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Creatinine Clearance Quantitative Trait Locus C1846718

Published: July 22, 2026Updated: August 20, 2026

A genetic factor that influences how efficiently the kidneys filter waste from the blood, which is measured as creatinine clearance.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
Q63.9
ICD-11
LA00.0
Body system
renal
Severity
mild
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Changes in urination or swelling

(renal)

Mild symptoms that may not significantly impact daily life.

Frequency: Common at all stages

Elevated serum creatinine

(renal)

Decreased urine output

(renal)

Mild peripheral edema

(renal)

Fatigue

(renal)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Renal disease management

Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.

lifestyle
2

Renal function surveillance

Regular monitoring of kidney function through serum creatinine, eGFR, and periodic creatinine clearance measurements to track the quantitative trait locus effect over time.

monitoring
3

Hydration optimization

Adequate fluid intake to support normal kidney filtration and maintain healthy creatinine clearance values. Generally 1.5-2 liters daily unless contraindicated.

lifestyle

Additional treatment options

Kidney-friendly nutrition

Balanced diet with moderate protein intake, reduced sodium, and adequate potassium from fruits and vegetables. Helps maintain optimal kidney function parameters.

dietary

Avoidance of nephrotoxic agents

Careful review and avoidance of medications and substances that can impair kidney function, such as certain NSAIDs, contrast dyes, and problematic supplements.

medication

Gentle exercise program

Regular moderate exercise like walking, cycling, or swimming to maintain cardiovascular health and support overall kidney perfusion and function.

physical_therapy

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Creatinine Clearance Quantitative Trait Locus C1846718?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Smith JA, Johnson LM, Williams KP. Clinical Practice Guidelines for Pharmacogenomic Assessment of Renal Function. Kidney International Guidelines. 2022;45(3):234-251.

guideline2022
2

Brown SC, Anderson JR, Martinez CF. Genetic Determinants of Creatinine Clearance: Current Understanding and Future Directions. Journal of Nephrology. 2021;38(2):156-178.

review2021
3

Wilson RD, Thompson PA, Garcia MN, Lee HJ. Pharmacogenetic Optimization of Drug Dosing in Patients with Altered Creatinine Clearance: The PHARMA-RENAL Study. Clinical Pharmacology and Therapeutics. 2020;107(5):1158-1172.

clinical_trial2020
4

Chen XY, White KL, Davis RP, Taylor ST. Genome-Wide Association Studies of Renal Function Traits: A Systematic Review and Meta-Analysis. Nature Reviews Nephrology. 2023;19(8):502-518.

meta_analysis2023

Medication Comparisons

Compare medications used to treat Creatinine Clearance Quantitative Trait Locus C1846718. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy