Cutaneous Undifferentiated Pleomorphic Sarcoma C1275254
An aggressive cancer of the soft tissues under the skin. Usually affects older adults and is typically treated with surgery and sometimes additional therapies.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Rapidly enlarging soft tissue mass
Skin ulceration
Unexplained weight loss
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Local pain or tenderness
(oncologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Targeted drug therapy with dose adjustment
Active treatment with regular monitoring by a healthcare provider is recommended.
Wide local excision with tumor-free margins
Aggressive surgical removal of the tumor with generous margins to reduce recurrence risk, considered the primary treatment for cutaneous pleomorphic sarcoma.
Adjuvant radiation therapy
Post-operative radiation to destroy residual cancer cells and reduce local recurrence risk in high-grade soft tissue sarcomas.
Additional treatment options
Long-term oncological surveillance
Regular imaging and clinical examinations to detect local recurrence or metastatic disease, typically for 5-10 years minimum.
monitoringSystemic chemotherapy for advanced disease
Chemotherapy options for unresectable, metastatic, or recurrent disease, typically using anthracycline-based regimens.
medicationReconstructive surgery
Plastic surgical reconstruction following tumor excision to restore function and appearance, often using flaps or grafts.
surgicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Cutaneous Undifferentiated Pleomorphic Sarcoma C1275254?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy