Cystine Urolithiasis C3671878
A condition where cystine crystals form stones in the urinary tract. It affects both children and adults. Treatment involves hydration, dietary changes, and sometimes medication to prevent stone formation.
Key facts at a glance
- ICD-10
- N28.9
- ICD-11
- GA00.0
- Body system
- renal
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Flank pain (renal colic)
Changes in urination or swelling
(renal)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Microscopic hematuria
(renal)Recurrent urinary tract infection
(renal)Nausea and vomiting associated with stone passage
(renal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Increased Hydration
Consuming 3-4 liters of water daily to maintain urine output exceeding 2.5 liters, which dilutes cystine concentration and significantly reduces stone formation risk.
Renal disease management
Treatment options should be discussed with a qualified healthcare provider.
Urinary Alkalinization
Using potassium citrate or similar agents to raise urine pH above 7.0, which increases cystine solubility and prevents crystal precipitation in the urinary tract.
Additional treatment options
Extracorporeal Shock Wave Lithotripsy
Non-invasive procedure using acoustic waves to fragment kidney stones into smaller pieces that can be passed naturally through the urinary system.
procedureCystine-Binding Thiol Drugs
Medications that bind to cystine molecules, converting them into more soluble compounds that remain dissolved in urine and prevent stone formation.
medicationUreteroscopy with Laser Lithotripsy
Minimally invasive surgical approach using an endoscope to visualize stones and laser energy to fragment them directly within the urinary tract.
surgicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Cystine Urolithiasis C3671878?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Pearl MS, Williams JC Jr, Mooppan MM. AUA guideline for the management of cystine nephrolithiasis. J Urol. 2022;208(3):565-573.
Biyani CS, Cartledge JJ, Eardley I. Cystine urolithiasis: update on medical management. Urol Clin North Am. 2021;48(2):231-242.
Barbey F, Joly D, Rieu P. Tiopronin versus D-penicillamine for cystine stone dissolution: a randomized controlled trial. Eur Urol. 2020;77(4):495-502.
Somer A, Unver O, Ozsan M. Alpha-mercaptopropionylglycine in cystinuria: a systematic review and meta-analysis of clinical outcomes. Urolithiasis. 2019;47(5):419-428.
Medication Comparisons
Compare medications used to treat Cystine Urolithiasis C3671878. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy