Deficiency Or Absence Of Cytochrome B 245 C1844390
Absence of cytochrome b245 impairs the respiratory burst in immune cells, preventing them from killing certain bacteria and fungi. Affected individuals experience recurrent severe infections beginning in childhood. Treatment involves aggressive infection management and preventive antibiotics.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Invasive Aspergillus infection
Generalized symptoms
(immunologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Recurrent pneumonias
(respiratory)Skin and soft tissue abscesses
(skin)Granuloma formation in lymph nodes
(immunologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Antimicrobial prophylaxis
Continuous prophylactic antibiotics, typically trimethoprim-sulfamethoxazole, help prevent bacterial infections in patients with Chronic Granulomatous Disease whose immune cells cannot properly kill certain bacteria.
Targeted drug therapy with dose adjustment
Active treatment with regular monitoring by a healthcare provider is recommended.
Interferon-gamma therapy
Recombinant interferon-gamma injections enhance immune function and reduce the frequency of serious infections in CGD patients by improving the killing capacity of phagocytes.
Additional treatment options
Infection prevention measures
Avoiding exposure to environmental sources of catalase-positive organisms and maintaining good hygiene practices reduces infection risk. This includes avoiding gardening, construction sites, and handling standing water.
lifestyleIncision and drainage of abscesses
Surgical drainage of abscesses is often necessary as they may not respond to antibiotics alone. Early intervention prevents spread of infection and tissue damage.
procedureRegular infection surveillance
Frequent clinical monitoring and laboratory assessment help detect infections early before they cause significant tissue damage or sepsis. Regular imaging may be needed to evaluate for deep-seated infections.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Deficiency Or Absence Of Cytochrome B 245 C1844390?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy