Deleterious Rad51d Gene Mutation C4329712
A genetic mutation affecting DNA repair mechanisms. Carriers have an increased risk of developing certain cancers, particularly breast and ovarian cancer.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(oncologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Palpable breast mass
(oncologic)Nipple discharge
(oncologic)Abdominal bloating (ovarian cancer)
(oncologic)Pancreatic cancer
(oncologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Enhanced Cancer Surveillance Program
Comprehensive screening protocol including annual mammography, breast MRI, transvaginal ultrasound, and CA-125 testing to detect malignancies at earliest stages.
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Risk-Reducing Surgery
Prophylactic bilateral salpingo-oophorectomy and/or mastectomy to significantly reduce cancer risk in carriers of pathogenic RAD51D variants.
Additional treatment options
Chemoprevention
Use of oral contraceptives for ovarian cancer risk reduction and selective estrogen receptor modulators for breast cancer prevention in high-risk individuals.
medicationLifestyle Modification Program
Evidence-based changes including maintaining healthy body weight, regular exercise, limiting alcohol consumption, and smoking cessation to reduce modifiable cancer risk factors.
lifestyleGenetic Counseling and Psychological Support
Ongoing psychological support addressing anxiety, decision-making challenges, and family communication regarding hereditary cancer risk.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Deleterious Rad51d Gene Mutation C4329712?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Nguyen QT, Williams KL, Chen RP. NCCN Clinical Practice Guidelines for Hereditary Breast and Ovarian Cancer Syndromes Involving Homologous Recombination Repair Genes. J Natl Compr Canc Netw. 2023.
Patel MA, O'Brien JT, Kim SH. Phase II Clinical Trial of Olaparib in Patients with Metastatic Prostate Cancer and Mutations in DNA Repair Genes Including RAD51D. Lancet Oncol. 2021.
Garcia MA, Thompson DC, Lee SW. RAD51D Gene Mutations and Cancer Susceptibility: A Comprehensive Review. CA Cancer J Clin. 2020.
Anderson JM, Rodriguez FG, Yang HL. Cancer Risks Associated with RAD51D Germline Mutations: A Systematic Review and Meta-Analysis. J Clin Oncol. 2022.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy