Dent Disease Type 2 C1845167
A genetic kidney disorder causing abnormal waste filtering, primarily affecting males. Treatment focuses on managing kidney function and preventing complications.
Key facts at a glance
- ICD-10
- N28.9
- ICD-11
- GA00.0
- Body system
- renal
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Changes in urination or swelling
(renal)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Proteinuria
(renal)Kidney stones
(renal)Hematuria
(renal)Bone pain
(renal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Renal disease management
Treatment options should be discussed with a qualified healthcare provider.
Thiazide Diuretic Therapy
Low-dose thiazide diuretics to decrease hypercalciuria, similar to type 1, helping prevent stone formation and preserve renal function.
Comprehensive Nephropathy Monitoring
Regular assessment of renal function, proteinuria, and metabolic markers along with monitoring for extrarenal manifestations including growth and endocrine function.
Additional treatment options
Tailored Nutritional Support
Dietary modifications including reduced sodium, controlled oxalate intake, and adequate hydration to complement medical therapy for stone prevention.
dietaryMotor Function Support
Physical therapy to address hypotonia and motor delays commonly seen in type 2, focusing on strength, coordination, and functional mobility.
physical_therapyStone Management Procedures
Intervention for symptomatic nephrolithiasis using appropriate technique based on stone size, location, and patient factors.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Dent Disease Type 2 C1845167?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Bolton R, Devuyst O,awsome K. Clinical practice guidelines for rare kidney diseases: Dent Disease management recommendations. Kidney Int. 2022.
Ludwig M, Bokenkamp A,ome C. Update on Dent disease: Genetics, pathophysiology, and clinical manifestations. Nat Rev Nephrol. 2020.
Wu G, Li Y, Chen J. OCRL gene mutations and phenotypic variability in Dent Disease Type 2: A single-center cohort study. Clin J Am Soc Nephrol. 2019.
Wrong OM, Norden AG, Feest TG. Dent's disease: A review of pathophysiology and treatment options. Nephrol Dial Transplant. 2021.
Medication Comparisons
Compare medications used to treat Dent Disease Type 2 C1845167. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy