Depdc5 Related Focal Cortical Dysplasia Cn381426
A neurological condition where abnormal brain development causes focal seizures, linked to DEPDC5 gene variants. Seizure management with medications or surgery may be needed.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Focal impaired awareness seizures
Todd paralysis
Status epilepticus
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Cognitive impairment
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
mTOR inhibitor therapy
Targeted therapy using everolimus or sirolimus to address dysregulated mTOR pathway activity associated with DEPDC5 mutations. This approach targets the underlying pathophysiology rather than just symptom management.
Antiseizure medications
Standard antiepileptic drugs chosen based on seizure semiology and EEG findings. May be used in combination with targeted therapies for optimal seizure control.
Additional treatment options
Focal cortical resection
Surgical removal of the dysplastic cortical region identified through detailed pre-surgical mapping when seizures are refractory to medical management.
surgicalVagus nerve stimulation
Implantation of a device that delivers electrical stimulation to the vagus nerve, reducing seizure frequency through neuromodulation of cortical excitability.
procedureKetogenic diet therapy
High-fat, low-carbohydrate diet that induces ketone body production and can reduce seizure frequency through metabolic and neurochemical mechanisms.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Depdc5 Related Focal Cortical Dysplasia Cn381426?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
Compare medications used to treat Depdc5 Related Focal Cortical Dysplasia Cn381426. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy