Depdc5 Related Infantile Spasms Cn381424
A form of infantile spasms linked to DEPDC5 gene variants, causing clusters of jerking movements in infants. Early treatment with medications or specialized diets may help control seizures.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Infantile spasms
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Intellectual disability
(neurologic)Hypsarrhythmia on EEG
(neurologic)Suppression-burst pattern on EEG
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Targeted drug therapy with dose adjustment
Active treatment with regular monitoring by a healthcare provider is recommended.
ACTH or oral corticosteroids
First-line hormonal therapy for infantile spasms that works by suppressing the corticotropin-releasing hormone axis and reducing the abnormal electrical activity causing spasms.
Vigabatrin
GABA transaminase inhibitor that increases GABA levels in the brain, specifically effective for infantile spasms particularly when related to tuberous sclerosis complex.
Additional treatment options
Ketogenic diet
Metabolic therapy using ketone bodies as an alternative brain fuel, effective for drug-resistant infantile spasms in many patients.
dietaryVagus nerve stimulation
Neuromodulation device implantation providing chronic vagal stimulation, which can reduce spasm frequency and improve alertness in refractory cases.
procedureContinuous EEG monitoring
Regular EEG surveillance to assess for resolution of hypsarrhythmia and detect subclinical seizures, guiding treatment duration and modification.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Depdc5 Related Infantile Spasms Cn381424?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
Compare medications used to treat Depdc5 Related Infantile Spasms Cn381424. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy