Developmental And Epileptic Encephalopathy 31a C4225357
A severe neurodevelopmental disorder with early-onset epilepsy and intellectual disability. Care involves seizure management and multidisciplinary support for developmental needs.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Seizures
(neurologic)Global developmental delay
(neurologic)Microcephaly
(neurologic)Spasticity
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Anti-seizure medications (ASMs)
First-line pharmacological treatment using age-appropriate anti-seizure medications to control seizure activity and reduce EEG放电. Selection based on seizure type and genetic etiology when known.
Medication management with follow-up
Active treatment with regular monitoring by a healthcare provider is recommended.
Classic Ketogenic Diet
High-fat, low-carbohydrate diet that induces ketone body production and can significantly reduce seizure frequency in refractory cases. Requires careful supervision and regular monitoring of metabolic parameters.
Additional treatment options
Vagus Nerve Stimulation (VNS)
Surgically implanted device delivering electrical pulses to the vagus nerve to reduce seizure frequency and severity. Often considered when medications and diet fail to provide adequate control.
procedureIntensive Early Intervention Therapy
Multidisciplinary rehabilitation approach including physical, occupational, and speech therapy to address developmental delays and motor impairments associated with the condition.
physical_therapyComprehensive Seizure and Developmental Monitoring
Regular neurological assessments, EEG monitoring, and developmental evaluations to track disease progression and adjust treatment plans accordingly.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Developmental And Epileptic Encephalopathy 31a C4225357?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy