Developmental And Epileptic Encephalopathy 67 C4748341
A rare genetic disorder causing frequent seizures and significant developmental challenges from infancy. Management includes anti-seizure medications and supportive therapies.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Early-onset infantile spasms
Focal neurological deficits
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Severe motor impairment
(neurologic)Progressive choreoathetosis
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Personalized anti-seizure medication selection
Carefully selected ASMs based on individual factors including seizure type, comorbidities, and genetic variants when identified. Regular review and optimization is essential.
Targeted drug therapy with dose adjustment
Active treatment with regular monitoring by a healthcare provider is recommended.
Classic ketogenic diet
Strict ketogenic diet with precise macronutrient ratios (typically 3:1 or 4:1 fat to protein+carbohydrate) administered under close metabolic supervision.
Additional treatment options
Applied behavior analysis (ABA) therapy
Structured behavioral intervention addressing communication, social skills, and maladaptive behaviors commonly seen in developmental encephalopathies.
psychologicalCorpus callosotomy
Surgical procedure dividing the corpus callosum to reduce seizure spread and severity, particularly beneficial for atonic (drop) seizures.
surgicalSleep hygiene and seizure safety measures
Comprehensive lifestyle modifications including consistent sleep schedule, environmental modifications to prevent injuries during seizures, and stress reduction techniques.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Developmental And Epileptic Encephalopathy 67 C4748341?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy