Developmental And Epileptic Encephalopathy 80 C5231418
A severe early-onset epilepsy syndrome associated with developmental delay or regression. Management includes anti-seizure medications and therapies to support development.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Seizures
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Developmental delay
(neurologic)Hypotonia
(neurologic)Dystonia
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Polytherapy anti-seizure management
Combination anti-seizure medication strategy when single agents prove insufficient. Requires careful balancing of efficacy against cumulative side effect burden.
Classic ketogenic diet
Strict medical-grade ketogenic diet administered under close metabolic supervision. Reserved for severe cases unresponsive to pharmacological interventions.
Additional treatment options
Family-centered counseling
Comprehensive psychological support for caregivers and family members managing the significant burden of severe epilepsy. Addresses caregiver stress, grief, and coping strategies.
psychologicalEmergency seizure rescue protocols
Development of individualized rescue medication plans for prolonged seizures and status epilepticus. Includes training for caregivers on appropriate administration.
procedureSeizure diary and wearable monitoring
Systematic tracking of seizure frequency, duration, and triggers using diary applications or approved wearable devices. Data informs treatment optimization decisions.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Developmental And Epileptic Encephalopathy 80 C5231418?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy