Developmental And Epileptic Encephalopathy 85 With Or Without Midline Brain Defects C5393312
A severe genetic epilepsy syndrome that may involve brain midline abnormalities, causing seizures and developmental delay. Treatment focuses on seizure control and supportive care.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Seizures
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Severe developmental delay
(neurologic)Hypotonia
(neurologic)Agenesis of corpus callosum
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Anti-seizure medications (ASMs)
Pharmacological management using anti-seizure medications tailored to seizure type. Treatment selection should be guided by EEG findings and individualized based on seizure semiology and genetic findings.
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Ketogenic diet therapy
High-fat, low-carbohydrate diet that may help reduce seizure frequency. Requires careful monitoring by a metabolic team and regular assessment of nutritional status and metabolic markers.
Additional treatment options
Physical and occupational therapy
Comprehensive rehabilitation services to address motor delays, hypotonia, and functional limitations associated with developmental encephalopathy.
physical_therapyVagus nerve stimulation (VNS)
Neurostimulation device implanted to deliver electrical pulses to the vagus nerve, potentially reducing seizure frequency in medication-resistant cases.
procedureRegular EEG and developmental monitoring
Ongoing neurophysiological monitoring combined with periodic developmental assessments to track disease progression and treatment response.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Developmental And Epileptic Encephalopathy 85 With Or Without Midline Brain Defects C5393312?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
Compare medications used to treat Developmental And Epileptic Encephalopathy 85 With Or Without Midline Brain Defects C5393312. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy