Developmental And Epileptic Encephalopathy 89 C5436853
A rare genetic condition combining hard-to-control seizures with profound developmental impairment due to a specific gene mutation.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Cortical visual impairment
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Seizures
(neurologic)Developmental delay
(neurologic)Spasticity
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Anti-seizure medications (ASMs)
First-line pharmacological treatment using age-appropriate anti-seizure medications selected based on seizure type and patient tolerability. Response varies significantly among patients with developmental and epileptic encephalopathies.
Medication management with follow-up
Active treatment with regular monitoring by a healthcare provider is recommended.
Classic Ketogenic Diet
High-fat, low-carbohydrate therapeutic diet that induces ketone body production and can significantly reduce seizure frequency in refractory cases. Requires careful nutritional monitoring and gradual initiation under medical supervision.
Additional treatment options
Vagus Nerve Stimulation (VNS)
Implantable neurostimulation device that delivers electrical pulses to the vagus nerve, reducing seizure frequency and severity. Often considered when medications and dietary therapies are insufficient.
surgicalIntensive Physical Rehabilitation
Individualized physical therapy program targeting motor delays, muscle tone abnormalities, and functional mobility limitations commonly seen in developmental and epileptic encephalopathies.
physical_therapyNeurodevelopmental and Behavioral Support
Comprehensive psychological services including behavioral therapy, cognitive interventions, and family support to address developmental delays, behavioral challenges, and improve quality of life outcomes.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Developmental And Epileptic Encephalopathy 89 C5436853?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy