Diffuse Glioma H3 G34 Mutant Cn377580
An aggressive brain tumor with a specific genetic mutation affecting young people. Treatment includes surgery, radiation, and chemotherapy, but prognosis remains poor.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- fatal
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Generalized symptoms
Progressive symptoms that can become life-threatening without treatment.
Seek immediate medical attention if symptoms worsen.
Severe headache
Motor weakness
Seizure
(neurologic)Personality changes
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Maximal Safe Surgical Resection
Surgical removal of as much tumor tissue as possible while preserving neurological function. Extent of resection is a critical prognostic factor in glioma treatment.
Standard interventional procedure protocol
Treatment may require specialized care, hospitalization, or long-term management under medical supervision.
Radiation Therapy
Focal radiation treatment targeting the tumor bed and residual disease. Typically delivered over several weeks using advanced planning techniques to minimize damage to healthy brain tissue.
Additional treatment options
Adjuvant Chemotherapy
Systemic chemotherapy agents administered after surgery and radiation to target residual tumor cells. May be combined with radiation or given sequentially based on molecular markers.
medicationSerial MRI Surveillance
Regular magnetic resonance imaging to monitor treatment response, detect recurrence, and assess for disease progression. Imaging schedule adapts based on clinical status and treatment phase.
monitoringNeurorehabilitation
Targeted physical and occupational therapy to address motor deficits, improve functional independence, and support recovery following surgery and other treatments.
physical_therapyWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Diffuse Glioma H3 G34 Mutant Cn377580?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Louis DN, Perry A, Wesseling P, et al. WHO Classification of Tumors of the Central Nervous System. Neuro-Oncology. 2021;23(7):1231-1251.
Sturm D, Witt H, Hovestadt V, et al. Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. Acta Neuropathologica. 2012;124(5):665-677.
Korshunov A, Chavez L, Sharma T, et al. H3 wild-type thalamic glioma and H3 G34-mutant glioma have distinct methylation clusters. J Clin Invest. 2022;132(11):e158952.
Haase S, Bächli H, Autry D, et al. Pediatric-type high-grade gliomas with H3 G34 mutation have distinct molecular features and microenvironment. Neuropathology. 2023;43(2):89-104.
Medication Comparisons
Compare medications used to treat Diffuse Glioma H3 G34 Mutant Cn377580. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy