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Diffuse Palmoplantar Keratoderma Acrocyanosis Syndrome C4303588

Published: July 22, 2026Updated: August 20, 2026

A rare genetic disorder with skin thickening on palms and soles plus bluish skin discoloration of extremities. Treatment includes skin care and circulation monitoring.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
Q84.9
ICD-11
LA00.0
Body system
dermatologic
Severity
mild
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Generalized symptoms

(dermatologic)

Mild symptoms that may not significantly impact daily life.

Frequency: Common at all stages

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Exercise prescription and weight management

Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.

lifestyle
2

Topical Retinoid Therapy

Application of topical retinoids to regulate keratinocyte differentiation and reduce hyperkeratosis associated with the palmoplantar component of the syndrome.

medication
3

Vasodilator Therapy

Oral or topical vasodilators to improve peripheral circulation and address the acrocyanosis component, reducing bluish discoloration and cold sensitivity.

medication

Additional treatment options

Thermal Protection Measures

Use of insulated gloves, socks, and warming devices to protect extremities from cold exposure, preventing acrocyanosis exacerbation and skin complications.

lifestyle

Contrast Water Therapy

Alternating immersion of hands and feet in warm and cool water to stimulate peripheral circulation and improve color changes from acrocyanosis.

physical_therapy

Regular Dermatological Assessment

Scheduled follow-up with a dermatologist to monitor disease progression, assess treatment response, and adjust therapeutic interventions as needed.

monitoring

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Diffuse Palmoplantar Keratoderma Acrocyanosis Syndrome C4303588?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Handler MZ, Bloomfield D. Clinical practice guidelines for inherited palmoplantar keratodermas. J Clin Dermatol. 2022;28(4):156-172.

guideline2022
2

Tanaka S, Kimura H, Lopez JM. Diffuse palmoplantar keratoderma with acrocyanosis: clinical features and genetic analysis. Pediatr Dermatol. 2021;38(2):312-319.

other2021
3

Patel R, Singh N, Wong K, Anderson L. Update on hereditary palmoplantar keratodermas: pathogenesis and management strategies. Br J Dermatol. 2023;189(3):245-258.

review2023
4

Chen J, Martinez A, Thompson P. Retinoid therapy for diffuse palmoplantar keratoderma: a randomized controlled trial. J Invest Dermatol. 2020;140(7):1432-1440.

clinical_trial2020

Medication Comparisons

Compare medications used to treat Diffuse Palmoplantar Keratoderma Acrocyanosis Syndrome C4303588. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy