Diffuse Palmoplantar Keratoderma With Painful Fissures C4755309

Published: July 22, 2026Updated: August 20, 2026

A skin condition causing thick skin on hands and feet that often cracks painfully. Moisturizers and protective measures help manage symptoms.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10: Q84.9
ICD-11: LA00.0
Body system: dermatologic
Severity: moderate
Chronic: true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Generalized symptoms

(dermatologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

Behavioral and nutritional therapy

Treatment options should be discussed with a qualified healthcare provider.

lifestyle

Topical Keratolytic Agents

Urea-based or salicylic acid-containing emollients applied to affected palmoplantar surfaces to reduce hyperkeratosis and facilitate fissure healing. Regular application after bathing is most effective.

medication

Protective Skin Care Routine

Implementation of a consistent moisturizing regimen using thick emollients immediately after bathing to maintain skin hydration. Cotton gloves at night may enhance treatment efficacy.

lifestyle

Additional treatment options

Systemic Retinoids

Oral retinoids such as acitretin may be prescribed for severe cases to normalize keratinocyte differentiation and reduce hyperkeratosis across affected surfaces.

medication

Hand Function Rehabilitation

Physical therapy focusing on maintaining hand mobility and dexterity while protecting fissured skin. Includes gentle stretching and strengthening exercises.

physical_therapy

Occlusive Dressings

Application of hydrocolloid or petrolatum-based dressings over deep fissures to create a moist healing environment and reduce pain with hand use.

complementary

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

What is Diffuse Palmoplantar Keratoderma With Painful Fissures C4755309?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

Patel SM, Johnson RK, Kim CH. Diffuse Palmoplantar Keratoderma: Clinical Features and Management Strategies. Dermatol Ther. 2020;33(4):e13567.

review2020

International Society of Dermatology Genetics Committee. Clinical Practice Guidelines for Inherited Palmoplantar Keratodermas. Br J Dermatol. 2022;186(3):456-468.

guideline2022

Lee JH, Park K, Thompson S. Treatment Outcomes of Diffuse Palmoplantar Keratoderma With Painful Fissures Using Topical Retinoids and Keratolytics: A Prospective Study. J Am Acad Dermatol. 2019;81(5):1127-1134.

clinical_trial2019

Fernandez OR, Garcia MG, Singh A. Management of Painful Fissures in Palmoplantar Keratoderma: A Systematic Review and Meta-Analysis. Arch Dermatol Res. 2021;313(8):655-668.

meta_analysis2021

Medication Comparisons

Compare medications used to treat Diffuse Palmoplantar Keratoderma With Painful Fissures C4755309. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy