Diminished Msh6 Expression C6055319
A genetic condition where reduced MSH6 gene expression impairs DNA mismatch repair, increasing risk for colorectal and other cancers. Follows autosomal dominant inheritance. Cancer surveillance is key.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Abnormal uterine bleeding
Pelvic or lower abdominal pain
Early‑onset colorectal cancer
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Bowel habit changes
(oncologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Tailored MSH6 surveillance protocol
MSH6 carriers may have later cancer onset; surveillance typically begins at age 25-30. Includes biennial colonoscopy with optional upper endoscopy for gastric cancer screening.
Fiber-enriched dietary modification
High-fiber diet with increased consumption of whole grains, legumes, and vegetables promotes bowel regularity and may reduce colorectal adenoma formation.
Additional treatment options
Aspirin daily therapy
Daily aspirin at cardioprotective doses has demonstrated cancer prevention benefits in Lynch syndrome. Continue indefinitely unless contraindicated.
medicationFamily cascade testing support
Facilitation of genetic testing for at-risk relatives through dedicated genetic counseling programs. Addresses emotional and logistical barriers to family testing.
psychologicalWeight management and physical activity
Maintaining healthy BMI through regular exercise and diet reduces overall cancer risk. Aim for 150 minutes weekly moderate activity.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Diminished Msh6 Expression C6055319?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy