Disease With Diffuse Palmoplantar Keratoderma As A Major Feature C5679958
Thickening of skin across the entire palms and soles. Can be inherited or acquired. Treatment uses skin-softening creams and careful care.
Key facts at a glance
- ICD-10
- Q84.9
- ICD-11
- LA00.0
- Body system
- dermatologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(dermatologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Topical Keratolytic Therapy
Application of topical agents containing urea, salicylic acid, or lactic acid to reduce hyperkeratosis, soften thickened skin, and improve pliability.
Systemic Retinoid Therapy
Oral retinoid medications that normalize keratinocyte differentiation and reduce excessive skin scaling through vitamin A derivative mechanisms.
Additional treatment options
Aggressive Skin Moisturization
Regular application of thick emollients and occlusive moisturizers throughout the day to maintain skin hydration and barrier function.
lifestyleVitamin A-Supplemented Diet
Dietary modifications including increased intake of vitamin A-rich foods to support skin health and epithelial maintenance.
dietaryMechanical Debridement
Regular gentle removal of excess scale using pumice stones, soft brushes, or professional debridement to maintain skin thickness.
physical_therapyWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Disease With Diffuse Palmoplantar Keratoderma As A Major Feature C5679958?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Patel GK, Chen SC. Consensus guidelines for diffuse palmoplantar keratoderma management. Br J Dermatol. 2022.
Wang LM, Rodriguez-Lopez EM, Tanaka R. Palmoplantar keratodermas: Clinical and genetic spectrum. J Am Acad Dermatol. 2021.
Martinez-Mendez ME, Ito S, Okada K. Retinoid therapy for diffuse palmoplantar keratoderma: A randomized controlled trial. JAMA Dermatol. 2020.
Schwartz AL, Nakamura T, Ferreira PP. Topical treatments for palmoplantar keratoderma: Systematic review and meta-analysis. Cochrane Database Syst Rev. 2023.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy