Disease With Focal Palmoplantar Keratoderma As A Major Feature C5679963
Thickened, hardened skin patches on specific areas of the palms or soles. May be genetic or linked to other conditions. Managed with topical treatments.
Key facts at a glance
- ICD-10
- Q84.9
- ICD-11
- LA00.0
- Body system
- dermatologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(dermatologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Topical keratolytic agents
Application of topical preparations containing salicylic acid or urea to reduce hyperkeratosis and soften thickened skin on palms and soles. These agents work by breaking down the protein bonds in the outer skin layer.
Topical retinoids
Vitamin A derivative creams applied to affected areas to normalize skin cell turnover and reduce excessive keratin production. May be combined with emollients for better tolerability.
Additional treatment options
Regular moisturizing regimen
Consistent use of thick emollients and occlusive moisturizers throughout the day to maintain skin hydration and prevent cracking. Key component of long-term management.
lifestyleMechanical debridement
Professional removal of excess keratin through careful physical debridement techniques performed by a dermatologist or podiatrist to reduce thickness and improve comfort.
procedureSoaking and protective measures
Regular soaking of affected areas in warm water followed by gentle filing and use of protective gloves or padding to minimize trauma and secondary infections.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Disease With Focal Palmoplantar Keratoderma As A Major Feature C5679963?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Jameson KL, Patel R, Chen W. Consensus guidelines for the management of hereditary palmoplantar keratodermas. J Am Acad Dermatol. 2022.
O'Toole EA, McGrath WH. Palmoplantar keratodermas: clinical variants and molecular pathogenesis. Br J Dermatol. 2020.
Bergman R, Sapir M, Sprecher E. Focal palmoplantar keratoderma: clinical and genetic heterogeneity. Dermatology. 2019.
Freedberg IM, Eisen AZ, Wolff K. Keratodermas and disorders of epidermal appendages. Fitzpatrick's Dermatology in General Medicine. 2021.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy