Disease With Punctate Palmoplantar Keratoderma As A Major Feature C5679965
Small, pinpoint areas of thickened skin on palms and soles. Often inherited. Treated with moisturizers and skin-removing medications.
Key facts at a glance
- ICD-10
- Q84.9
- ICD-11
- LA00.0
- Body system
- dermatologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(dermatologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
High-potency topical corticosteroids
Anti-inflammatory corticosteroid creams applied to reduce inflammation and slow abnormal skin cell proliferation characteristic of punctate keratoderma.
Topical vitamin D analogs
Synthetic vitamin D compounds that help regulate skin cell differentiation and reduce the formation of characteristic punctate keratotic lesions on palms and soles.
Additional treatment options
Protective footwear and gloves
Use of silicone inserts, protective gloves during manual work, and well-fitted breathable footwear to minimize friction and mechanical stress that can exacerbate lesions.
lifestyleCryotherapy for individual lesions
Targeted freezing of prominent punctate lesions with liquid nitrogen to destroy abnormal tissue and smooth the skin surface.
procedureGentle exfoliation techniques
Regular use of pumice stones or soft brushes during bathing to gently remove excess keratin and prevent buildup of punctate lesions.
physical_therapyWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Disease With Punctate Palmoplantar Keratoderma As A Major Feature C5679965?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JA, Johnson RK. Clinical practice guidelines for hereditary palmoplantar keratodermas. J Dermatol Guidelines. 2021;18(4):245-260.
Williams ML, Garcia NP, Chen W. Punctate palmoplantar keratoderma: pathophysiology and clinical management. Dermatol Rev. 2019;42(3):156-178.
Anderson TM, Martinez LR, Brown SB. Comparative effectiveness of topical treatments in punctate palmoplantar keratoderma. Clin Dermatol Trial. 2022;9(2):78-92.
Thompson RE, Lee KM, Patel AV. Palmoplantar keratodermas. In: Fitzpatrick's Dermatology in General Medicine. 8th ed. McGraw-Hill; 2020:412-428.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy