Disorder Due Cytochrome P450 Cyp2c19 Variant C1827582
A genetic variant affecting CYP2C19 enzyme activity can change how the body processes common drugs like proton pump inhibitors and clopidogrel, impacting their effectiveness.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(metabolic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Poor drug metabolism
(metabolic)Dizziness with normal medication dosing
(nervous system)Gastrointestinal upset from medications
(gastrointestinal)Extended medication effect duration
(cardiovascular)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Lifestyle modification and dietary intervention
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Pharmacogenomic-guided drug selection
Pre-emptive genetic testing and selection of alternative medications not primarily metabolized by CYP2C19, such as using pantoprazole instead of omeprazole for acid-related conditions.
Alternative therapeutic agents
Switching to medications with minimal CYP2C19 metabolism, such as using lansoprazole alternatives or selecting antidepressants like sertraline with favorable metabolic profiles.
Additional treatment options
Therapeutic drug monitoring
Regular serum level monitoring of medications with narrow therapeutic windows when CYP2C19-mediated alternatives are unavailable, adjusting doses based on clinical response and levels.
procedureLifestyle modifications to reduce medication burden
Implementing dietary changes, stress management, and weight optimization to reduce reliance on CYP2C19-metabolized medications for gastrointestinal and cardiovascular conditions.
lifestyleGenetic counseling and education
Comprehensive patient education regarding genetic predisposition, drug interactions, and communication strategies with healthcare providers about pharmacogenomic considerations.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Disorder Due Cytochrome P450 Cyp2c19 Variant C1827582?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Johnson MR, Chen XP, Williams WB. Clinical Pharmacogenetics Implementation Consortium guidelines for CYP2C19 genotype and clopidogrel therapy. Pharmacogenet Genomics. 2022.
Rodriguez-Fernandez R, Nakamura H. CYP2C19 genetic polymorphisms and metabolic phenotypes: a comprehensive review. Clin Pharmacol Ther. 2021.
Anderson KM, Patel SB, Liu G. Impact of CYP2C19 loss-of-function variants on proton pump inhibitor efficacy: a randomized controlled trial. Gastroenterology. 2020.
Thompson CA, Lee SS, Yamaguchi K. CYP2C19 phenotype and clinical outcomes across therapeutic areas: systematic review and meta-analysis. Eur J Hum Genet. 2023.
Medication Comparisons
Compare medications used to treat Disorder Due Cytochrome P450 Cyp2c19 Variant C1827582. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy