Disorder Due Cytochrome P450 Cyp2d6 Variant C6066005
A genetic variant affecting CYP2D6 enzyme activity impacts how the body processes many antidepressants, antipsychotics, and pain medications, affecting treatment outcomes.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(metabolic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Impaired medication clearance
(metabolic)Cognitive fog with normal medication doses
(nervous system)Orthostatic intolerance with medications
(cardiovascular)Photosensitivity reactions
(integumentary)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Codeine and tramadol avoidance
Avoiding opioids dependent on CYP2D6 activation such as codeine and tramadol, substituting with morphine, hydromorphone, or non-opioid analgesics based on pain severity.
Alternative antidepressant selection
Selecting antidepressants not dependent on CYP2D6 metabolism such as bupropion, mirtazapine, or sertraline instead of fluoxetine, paroxetine, or amitriptyline.
Additional treatment options
Adverse effect surveillance
Enhanced clinical monitoring for symptoms of poor or ultra-rapid drug metabolism including signs of opioid toxicity, serotonin syndrome, or therapeutic failure.
monitoringNon-pharmacological pain management
Cognitive behavioral therapy, physical therapy modalities, and nerve block procedures as alternatives or adjuncts to opioid medications in chronic pain management.
psychologicalAntipsychotic alternative strategies
Selecting antipsychotics with favorable metabolic profiles based on CYP2D6 status, considering aripiprazole or quetiapine over risperidone or haloperidol when appropriate.
medicationWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Disorder Due Cytochrome P450 Cyp2d6 Variant C6066005?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Caudle KE, Gammal RS, Sangkuhl K, et al. Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6 Genotype and Use of CYP2D6-Interacting Medications. Clin Pharmacol Ther. 2022.
Zhou SF. Polymorphism of human cytochrome P450 2D6 and its clinical significance. Pharmacogenomics J. 2019.
Tomasello C, Roncato R, Macchia T, De Girolamo G. Impact of CYP2D6 Polymorphism on Adverse Drug Reactions in Psychiatric Patients. Br J Clin Pharmacol. 2020.
Stingl JC, Brockmoller J, Viviani R. CYP2D6 Polymorphism and Response to Codeine Therapy. Pharmacogenomics. 2018.
Medication Comparisons
Compare medications used to treat Disorder Due Cytochrome P450 Cyp2d6 Variant C6066005. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy