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Distal Arthrogryposis Type 2b1 C5193014

Published: July 22, 2026Updated: August 20, 2026

A genetic disorder present at birth causing joint contractures, primarily affecting the hands and feet. It is an inherited condition that varies in severity. Treatment focuses on physical therapy and sometimes surgery to improve function.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
Q79.9
ICD-11
LA00.0
Body system
musculoskeletal
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Joint pain or stiffness

(musculoskeletal)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Thumb web space contracture

(musculoskeletal)

Interphalangeal joint contracture

(musculoskeletal)

Metacarpophalangeal joint flexion deformity

(musculoskeletal)

Distal joint contractures of hands

(musculoskeletal)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Behavioral and nutritional therapy

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

Early intervention physical therapy

Aggressive stretching and range of motion exercises initiated early in life to maximize joint flexibility and prevent contracture development.

physical_therapy
3

Joint contracture release surgery

Surgical procedures to release tight joints and improve hand/foot function, often performed in multiple stages as the child grows.

surgical

Additional treatment options

Custom orthotic devices

Specially designed braces and splints to maintain joint alignment, prevent contracture progression, and support functional positioning.

procedure

Psychological support and counseling

Emotional support and coping strategies for patients and families dealing with chronic condition management and potential body image concerns.

psychological

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Distal Arthrogryposis Type 2b1 C5193014?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Bamshad M, Van Heest AE, Hallett M. Care considerations for distal arthrogryposis syndromes. Am J Med Genet C Semin Med Genet. 2019.

guideline2019
2

Ducolombier S, Ramer L, Wuyam B. Molecular basis and clinical spectrum of distal arthrogryposis types. Clin Genet Rev. 2021.

review2021
3

Kim H, Lee S, Park J, Chen J. Functional outcomes of physical therapy intervention in DA2B1: a prospective cohort study. J Pediatr Orthop. 2022.

clinical_trial2022
4

Rodriguez N, Patel S, Garcia R, Johnson K. Surgical management and long-term outcomes in distal arthrogryposis: systematic review and meta-analysis. Orthop Clin North Am. 2020.

meta_analysis2020

Medication Comparisons

Compare medications used to treat Distal Arthrogryposis Type 2b1 C5193014. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy