Dnajc6 Juvenile Parkinson Disease Cn381347
A genetic form of parkinsonism that begins in childhood or adolescence. Causes movement difficulties including tremors and stiffness that can progress over time. Treatment aims to manage motor symptoms.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Bradykinesia
(neurologic)Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Resting tremor
(neurologic)Cognitive decline
(neurologic)Autonomic dysfunction
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Levodopa-Carbodopa Therapy
Dopamine replacement therapy remains the cornerstone of treatment for parkinsonian symptoms. Initiated at diagnosis and titrated based on response and side effect profile.
MAO-B Inhibitors
Adjunctive therapy to help prolong the effect of dopamine and potentially provide neuroprotective benefits when combined with levodopa therapy.
Additional treatment options
Intensive Physical Therapy
Structured exercise program focusing on gait training, balance exercises, and functional mobility to maintain independence and slow disease progression.
physical_therapyDeep Brain Stimulation
Surgical implantation of electrodes in specific brain regions for patients with advanced disease who experience significant motor fluctuations or dyskinesias unresponsive to medication adjustments.
surgicalExercise and Activity Program
Regular aerobic exercise, stretching, and strength training to maintain motor function, improve mood, and support overall neurological health.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Dnajc6 Juvenile Parkinson Disease Cn381347?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy