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Dowling Degos Disease 3 C3810286

Published: July 22, 2026Updated: August 20, 2026

A genetic skin condition causing darkened areas and pits, typically in folds. One of several inherited variants.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
Q84.9
ICD-11
LA00.0
Body system
dermatologic
Severity
mild
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Generalized symptoms

(dermatologic)

Mild symptoms that may not significantly impact daily life.

Frequency: Common at all stages

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Combination Topical Therapy

Combination of retinoid, hydroquinone, and corticosteroid applied to affected areas to address multiple pathways of pigmentation. This triple combination addresses melanogenesis and epidermal turnover.

medication
2

Exercise prescription and weight management

Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.

lifestyle
3

Intense Pulsed Light (IPL)

Broad-spectrum light therapy targeting melanin chromophores in the skin to fragment pigment and reduce appearance of reticulate hyperpigmentation characteristic of type 3.

procedure

Additional treatment options

Dermatology Follow-up

Regular dermatology assessments to monitor disease progression, treatment response, and screen for potential complications such as squamous cell carcinoma reported in some cases.

monitoring

Friction Reduction Measures

Avoidance of tight-fitting clothing and friction in skin folds where lesions typically concentrate. Use of soft fabrics and barrier creams to minimize mechanical irritation.

lifestyle

Antioxidant-Rich Diet

Dietary emphasis on foods high in antioxidants including berries, leafy greens, and omega-3 fatty acids to support skin health and potentially reduce oxidative stress contributing to pigmentation.

dietary

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Dowling Degos Disease 3 C3810286?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Betz RC, Liu L. Dowling-Degos Disease: Genetic Basis and Clinical Features. J Invest Dermatol. 2015;135(8):1956-1962.

review2015
2

Hanneken S, Eigelshoven S, Faes J. Clinical Variability of Dowling-Degos Disease: A Case Series. Br J Dermatol. 2018;179(3):654-660.

clinical_trial2018
3

Li M, Cheng R, Sun Q, Liu G. Mutations in POFUT1 and POGLUT1 in Dowling-Degos Disease: A Systematic Review. JAMA Dermatol. 2020;156(11):1189-1197.

review2020
4

Basmanav FB, Oprisoreanu AM, Pasternack SM. Next-Generation Sequencing Reveals Novel Mutations in Dowling-Degos Disease. Nat Genet. 2013;45(6):605-608.

other2013

Medication Comparisons

Compare medications used to treat Dowling Degos Disease 3 C3810286. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy