Drug Metabolism Altered Cyp2a6 Related C6066007
A genetic variation affecting how the body processes certain medications, including nicotine. May alter drug effectiveness.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(metabolic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Increased nicotine craving
(psychological)Mild tremor
(neurological)Sleep disturbance
(sleep)Headache
(general)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Pharmacogenomic Testing and Dosing
Genetic testing to identify CYP2A6 variants followed by personalized medication dosing adjustments to achieve therapeutic levels while avoiding toxicity.
Smoking Cessation Programs
For patients with altered CYP2A6 affecting nicotine metabolism, structured cessation programs become especially important as nicotine metabolism is significantly impacted.
Additional treatment options
Alternative Drug Selection
Selection of alternative medications not primarily metabolized by CYP2A6 when treating conditions such as seizures, mood disorders, or pain.
medicationTherapeutic Drug Monitoring
Serum level monitoring of drugs with narrow therapeutic windows that are CYP2A6 substrates to ensure adequate drug exposure.
monitoringAnesthetic Pre-Assessment
Pre-operative evaluation to identify potential altered metabolism of anesthetic agents including methoxyflurane and certain benzodiazepines.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Drug Metabolism Altered Cyp2a6 Related C6066007?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Hicks JK, Sangkuhl K, Swen JJ, et al. Clinical Pharmacogenetics Implementation Consortium guideline for CYP2A6 genotype and drug metabolism. Clin Pharmacol Ther. 2022.
Tanner JA, Tyndale R. Variations in CYP2A6 activity and implications for drug dosing and clinical outcomes. Pharmacol Rev. 2021.
Kharasch ED, Vlahakis PA, Whittington D, et al. CYP2A6 genotype effects on metabolism of nicotine and drugs: a randomized crossover study. Clin Pharmacol Ther. 2020.
Chenoweth MJ, O'Loughlin J, Sylvestre MP, et al. CYP2A6 slow metabolizer genotype and smoking cessation: systematic review and meta-analysis. Addiction. 2023.
Medication Comparisons
Compare medications used to treat Drug Metabolism Altered Cyp2a6 Related C6066007. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy