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Drug Metabolism Altered Cyp2c19 Related C6066008

Published: July 22, 2026Updated: August 27, 2026

A genetic variation affecting how the body processes common drugs. May influence response to certain antidepressants and antacids.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 27, 2026Editorial policy

Key facts at a glance

ICD-10
E88.9
ICD-11
5A00.0
Body system
metabolic
Severity
mild
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Fatigue or weight changes

(metabolic)

Mild symptoms that may not significantly impact daily life.

Frequency: Common at all stages

Mild bruising

(hematologic)

Gastrointestinal discomfort

(gastrointestinal)

Dizziness

(nervous)

Headache

(general)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Lifestyle modification and dietary intervention

Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.

lifestyle
2

Pharmacogenomic-Guided Prescribing

Pre-emptive genetic testing to identify CYP2C19 variants before prescribing medications commonly metabolized by this enzyme including PPIs, clopidogrel, and certain antidepressants.

monitoring
3

Proton Pump Inhibitor Alternatives

For CYP2C19 poor metabolizers resistant to PPI therapy, H2 receptor antagonists or alternative acid suppression strategies may be employed.

medication

Additional treatment options

Clopidogrel Alternative Therapy

Patients with reduced CYP2C19 function requiring antiplatelet therapy may need alternative agents such as prasugrel or ticagrelor instead of clopidogrel.

medication

Antidepressant Response Monitoring

Close monitoring of therapeutic response and side effects when prescribing SSRIs or tricyclic antidepressants metabolized by CYP2C19.

monitoring

Lifestyle Modification for GERD

Dietary and behavioral changes including weight management, meal timing adjustments, and sleep position modifications to reduce PPI dependence.

complementary

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Drug Metabolism Altered Cyp2c19 Related C6066008?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Hicks JK, Sangkuhl K, Swen JJ, et al. Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2C19 Genotype and Clopidogrel Therapy. Clin Pharmacol Ther. 2017.

guideline2017
2

Scott SA, Sangkuhl K, Stein CM, et al. Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C19 Genotype and Voriconazole Therapy. Pharmacogenet Genomics. 2013.

review2013
3

Sorich MJ, Polasek TM, Wiese MD. Systematic Review and Meta-analysis of the Association between CYP2C19 Polymorphisms and Medication Adverse Events. Clin Pharmacol Ther. 2014.

meta_analysis2014
4

Brennan Z, Thiesen A, Tanaka Y, et al. Randomized Controlled Trial of CYP2C19-guided Proton Pump Inhibitor Dosing in Healthy Volunteers. Clin Pharmacokinet. 2022.

clinical_trial2022

Medication Comparisons

Compare medications used to treat Drug Metabolism Altered Cyp2c19 Related C6066008. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy