Drug Metabolism Ultrarapid Cyp2d6 Related C1837155
A genetic variation causing the CYP2D6 enzyme to process certain medications faster than normal. People with this condition may need adjusted doses for common drugs including some antidepressants and pain medications. Healthcare providers can test for this and personalize treatment accordingly.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(metabolic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Increased sensitivity to analgesics
(pharmacological)Anxiety
(psychological)Insomnia
(sleep)Headache
(general)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
CYP2D6 substrate avoidance
Identification and avoidance of medications primarily metabolized by CYP2D6 enzyme. This includes many antidepressants, opioids, and antipsychotics that may have reduced efficacy or increased side effects in ultrarapid metabolizers. Patients should carry documentation of their pharmacogenetic profile.
Therapeutic drug monitoring
Regular blood level monitoring of medications metabolized by CYP2D6 to ensure therapeutic levels are maintained. This approach helps adjust dosages based on actual drug clearance rather than standard dosing protocols. Particularly important for medications with narrow therapeutic windows.
Additional treatment options
Alternative medication selection
Selection of medications that are metabolized through alternative pathways not affected by CYP2D6 polymorphism. This proactive approach reduces the need for extensive dose adjustments and minimizes trial-and-error prescribing. Involves consultation with clinical pharmacologists.
medicationPharmacogenetic testing
Comprehensive genetic testing to identify all relevant drug-metabolizing enzyme variants beyond CYP2D6. Results guide future medication choices across multiple therapeutic areas. Testing is typically one-time but results inform lifelong treatment decisions.
procedureAdverse drug reaction surveillance
Enhanced vigilance for unexpected medication responses or side effects that may indicate ultrarapid metabolism. Patients and caregivers are educated to recognize signs of suboptimal therapy or toxicity. Regular follow-up appointments allow for timely adjustments.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Drug Metabolism Ultrarapid Cyp2d6 Related C1837155?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Hicks JK, Bishop JR, Sangkuhl K, et al. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 Genotyping. Pharmacogenomics J. 2017.
Zhou Y, Ingelman-Sundberg M, Lauschke VM. CYP2D6 Polymorphisms and Variable Drug Metabolizer Phenotypes. Pharmacol Ther. 2020.
Nofziger C, Turner AJ, target JD, et al. Impact of CYP2D6 Ultrarapid Metabolism on Codeine Efficacy and Safety. Clin Pharmacol Ther. 2019.
Wang D, Chen Y, Guo L, et al. Meta-Analysis of CYP2D6 Genotype and Tamoxifen Outcomes in Breast Cancer Patients. J Clin Oncol. 2021.
Medication Comparisons
Compare medications used to treat Drug Metabolism Ultrarapid Cyp2d6 Related C1837155. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy