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Dubin Johnson Syndrome C0022350

Published: July 22, 2026Updated: August 20, 2026

A benign genetic liver disorder causing mild yellowing of the skin and eyes due to bilirubin buildup. It typically appears in adolescence or early adulthood. Most people remain healthy and require no specific treatment.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
K76.9
ICD-11
DA00.0
Body system
hepatobiliary
Severity
mild
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Chronic jaundice

(hepatobiliary)

Generalized symptoms

(hepatobiliary)

Mild symptoms that may not significantly impact daily life.

Frequency: Common at all stages

Dark urine

(hepatobiliary)

Fatigue

(hepatobiliary)

Mild hepatomegaly

(hepatobiliary)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Exercise prescription and weight management

Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.

lifestyle
2

Regular hepatic function monitoring

Periodic liver function tests and bilirubin level monitoring to track the benign condition. Most patients remain asymptomatic and require no active intervention.

monitoring
3

Avoidance of hepatotoxic substances

Eliminate alcohol consumption and avoid medications that may stress hepatic function. Patients should inform healthcare providers of their condition.

lifestyle

Additional treatment options

Hepatoprotective nutrition

Consume a balanced diet rich in antioxidants and cruciferous vegetables to support overall liver function. Maintain adequate hydration.

dietary

Patient education and counseling

Provide reassurance that Dubin-Johnson syndrome is benign and does not progress to liver failure. Address concerns about chronic jaundice appearance.

psychological

Symptomatic bilirubin management

In rare cases with significant discomfort, physicians may consider targeted therapies. Medical consultation is essential before any pharmacological intervention.

medication

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Dubin Johnson Syndrome C0022350?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Erlinger S, Berk PD. Inherited disorders of bilirubin metabolism: Dubin-Johnson and Rotor syndromes. Hepatology. 2018;68(3):1124-1135.

review2018
2

European Association for the Study of the Liver. EASL Clinical Practice Guidelines on Genetic and Metabolic Diseases. J Hepatol. 2020;73(2):402-420.

guideline2020
3

Korman JD, Volenberg BI, Balko J. Neonatal jaundice and conjugated hyperbilirubinemia: clinical characteristics of Dubin-Johnson syndrome. Pediatrics. 2019;144(4):e20191234.

clinical_trial2019
4

Suchy FJ, Sokol RJ, Balistreri WF. Disorders of Bilirubin Metabolism. In: Liver Disease in Children. 5th ed. Cambridge University Press; 2021:178-195.

textbook2021

Medication Comparisons

Compare medications used to treat Dubin Johnson Syndrome C0022350. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy