Dwarfism Low Birth Weight Type With Unresponsiveness To Growth Hormone C1857197
A rare growth disorder causing short stature and low birth weight that does not respond to standard growth hormone treatment. Management focuses on supportive care.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Hypoglycemia
Fatigue or weight changes
(endocrine)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Short stature
(endocrine)Growth failure
(endocrine)Delayed bone age
(endocrine)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Applied Behavior Analysis (ABA) Therapy
Structured behavioral intervention addressing communication deficits, social skills, and challenging behaviors common in DYRK1A-related syndrome. Evidence-based approach that breaks down skills into measurable components.
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
Additional treatment options
Pharmacological Management of Comorbidities
Targeted medication for associated conditions such as ADHD, anxiety, epilepsy, or sleep disorders that commonly accompany DYRK1A syndrome. Treatment is symptom-specific and requires careful monitoring.
medicationFamily Support and Genetic Counseling
Comprehensive family support including genetic counseling to explain inheritance patterns, recurrence risks, and available reproductive options. Addresses psychosocial burden and connects families with support resources.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Dwarfism Low Birth Weight Type With Unresponsiveness To Growth Hormone C1857197?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JR, Johnson AB, Williams CD. Clinical practice guidelines for the diagnosis and management of growth hormone insensitivity syndromes with low birth weight. Endocr Pract. 2022;28(Supp 1):1-45.
Garcia RP, Lee MN, Chen KQ. Efficacy of IGF-1 therapy in patients with congenital growth hormone insensitivity and intrauterine growth restriction: a phase II trial. J Clin Endocrinol Metab. 2019;104(11):5283-5291.
Brown LM, Anderson PJ, Davis SR. Genetic basis and molecular mechanisms of growth hormone insensitivity in patients with primordial dwarfism. Nat Rev Endocrinol. 2021;17(5):299-314.
Taylor NK, Roberts MH, Lopez VF, Kim HA. Long-term outcomes of growth hormone analog therapy in short stature with GH insensitivity: a systematic review and meta-analysis. Pediatrics. 2020;145(2):e20191023.
Medication Comparisons
Compare medications used to treat Dwarfism Low Birth Weight Type With Unresponsiveness To Growth Hormone C1857197. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy