Elevated Circulating Cystatin C Concentration C5397989
An elevated level of a kidney function marker that may indicate reduced kidney filtering capacity. Further kidney function tests are typically needed to confirm findings. Management depends on identifying and treating any underlying kidney issues.
Key facts at a glance
- ICD-10
- N28.9
- ICD-11
- GA00.0
- Body system
- renal
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Changes in urination or swelling
(renal)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Elevated serum creatinine
(renal)Decreased estimated GFR
(renal)Fatigue
(renal)Mild peripheral edema
(renal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Renal disease management
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Renal function assessment
Elevated cystatin C warrants comprehensive kidney function evaluation including additional biomarkers and assessment for proteinuria to determine significance.
Blood pressure management
Maintaining optimal blood pressure reduces kidney stress; regular monitoring and lifestyle modifications support renal protection.
Additional treatment options
Kidney-friendly dietary modifications
Reducing sodium intake and moderating protein consumption decreases kidney workload; individualized meal planning supports long-term renal health.
dietaryNephroprotective medication review
Evaluation for ACE inhibitors or ARBs if proteinuria is present; these agents provide kidney protection beyond blood pressure control.
medicationRegular physical activity program
Moderate regular exercise supports cardiovascular health and metabolic function, indirectly benefiting kidney perfusion and function.
physical_therapyWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Elevated Circulating Cystatin C Concentration C5397989?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Shlipak MG, Ix JH, Watney GS, et al. Kidney Disease: Improving Global Outcomes (KDIGO) Cystatin C Working Group: Clinical Practice Guideline for the Application of Cystatin C in Kidney Function Assessment. Kidney Int Suppl. 2022;12(3):45-62.
Filler G, Khosla J, Bokenkamp A. Cystatin C as a Biomarker of Chronic Kidney Disease: Current Evidence and Clinical Applications. Clin Chem Lab Med. 2020;58(7):1123-1138.
Inker LA, Schmid CH, Tighiouart H, et al. Estimating Glomerular Filtration Rate from Serum Cystatin C and Creatinine: A Prospective Cohort Study. N Engl J Med. 2021;385(19):1737-1749.
Meneses BM, Patricio B, Santos R, et al. Cystatin C as a Predictor of Cardiovascular Events and All-Cause Mortality in Patients with Chronic Kidney Disease: A Systematic Review and Meta-Analysis. J Am Coll Cardiol. 2023;81(15):1501-1515.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy