Elevated Circulating Galectin 3 Concentration C5139191
Galectin-3 is a protein involved in inflammation and tissue repair. Elevated levels are associated with heart failure, fibrosis, and various inflammatory conditions.
Key facts at a glance
- ICD-10
- I78.0
- ICD-11
- BA00.0
- Body system
- cardiovascular
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Chest discomfort or palpitations
(cardiovascular)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Reduced exercise tolerance
(cardiovascular)Mild dyspnea on exertion
(cardiovascular)Lower extremity edema
(cardiovascular)Palpitations
(cardiovascular)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Cardiac and renal monitoring
Implement regular monitoring of cardiac function through echocardiography and kidney function tests as galectin-3 elevation is associated with heart failure and CKD progression.
Disease management and monitoring
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Heart failure guideline-directed therapy
Optimize guideline-directed medical therapy for heart failure including appropriate use of ACE inhibitors, beta-blockers, and mineralocorticoid antagonists when underlying cardiac disease is present.
Additional treatment options
Sodium and fluid management
Restrict dietary sodium intake and monitor fluid balance to reduce cardiac workload and prevent fluid overload that may exacerbate galectin-3 associated conditions.
lifestyleHeart-healthy nutrition
Consume a heart-healthy diet pattern such as DASH or plant-based eating to support cardiovascular health and reduce inflammatory markers.
dietaryOmega-3 fatty acid supplementation
Consider omega-3 supplementation as an adjunctive therapy for anti-inflammatory and cardioprotective effects after consulting with a healthcare provider.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Elevated Circulating Galectin 3 Concentration C5139191?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
de Boer RA, Edelmann F, Cohen-Solal A, et al. Galectin-3 in heart failure: an update on pathophysiology and prognostic value. JACC Heart Fail. 2020;8(11):922-934.
McDonagh TA, Metra M, Adamo M, et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2021;42(36):3599-3726.
Gao MR, Yu B, Liu J, et al. Circulating galectin-3 and cardiovascular outcomes in heart failure patients: the GALA-HF trial. J Card Fail. 2022;28(5):745-753.
Lok SI, van der Meer P, Winkens B, et al. Prognostic value of galectin-3 in patients with chronic heart failure: a systematic review and meta-analysis. ESC Heart Fail. 2021;8(4):2953-2964.
Medication Comparisons
Compare medications used to treat Elevated Circulating Galectin 3 Concentration C5139191. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy