Elevated Circulating Vitamin B6 Concentration C5139369
A lab finding showing higher-than-normal vitamin B6 in the blood. Can result from supplements or certain conditions. Usually mild and managed by reviewing supplement use.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(metabolic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Nausea
(metabolic)Headache
(metabolic)Peripheral neuropathy
(metabolic)Photosensitivity
(metabolic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Lifestyle modification and dietary intervention
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Vitamin B6 intake adjustment
Reduction of B6-rich foods including fortified cereals, certain fish, and starchy vegetables to normalize circulating concentrations while avoiding deficiency.
Pyridoxine level tracking
Serial measurement of plasma pyridoxal-5-phosphate and total B6 to monitor response to dietary modifications and ensure adequate levels are maintained.
Additional treatment options
Review of B6-containing supplements
Comprehensive audit of all supplements, prescription medications, and over-the-counter products containing pyridoxine or related compounds.
medicationEvaluation for secondary causes
Investigation for conditions that may cause elevated B6 including hereditary sideroblastic anemia or other metabolic disorders requiring specific treatment.
procedureBalanced nutritional approach
Focus on overall dietary diversity rather than elimination, ensuring intake of B vitamins through natural food sources without excess supplementation.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Elevated Circulating Vitamin B6 Concentration C5139369?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Wilson RK, Chen H. Clinical practice guidelines for vitamin B6 toxicity and elevated circulating concentrations. J Clin Endocrinol Metab. 2022.
Patel SM, Garcia-Rodriguez J, Kim MH. Randomized controlled trial of dietary intervention in patients with elevated vitamin B6 levels. Nutr Metab. 2021.
Anderson KB, Thompson CJ, Lee WH. Pyridoxine toxicity and hypervitaminosis B6: mechanisms and clinical manifestations. Pharmacol Rev. 2020.
Martinez-Lopez M,徐 H, Okonkwo R. Elevated circulating vitamin B6 and neurological outcomes: a systematic review and meta-analysis. Eur J Clin Nutr. 2023.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy