Elevated Csf D Glyceric Acid Concentration C5937164
An elevated organic acid in cerebrospinal fluid that may indicate abnormalities in glycerate metabolism and can be associated with neurological symptoms.
Key facts at a glance
- ICD-10
- G31.82
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Seizures
Generalized symptoms
(neurologic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Intellectual disability
(neurologic)Microcephaly
(neurologic)Movement disorder
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Low glyceric acid precursor diet
Restriction of dietary sources that metabolize to D-glyceric acid, including reduced intake of fructose, sucrose, and glycerol-containing compounds. Consultation with a metabolic dietitian is essential for safe implementation.
B6 and thiamine supplementation
Empirical trial of pyridoxine (B6) and thiamine (B1) supplementation, which serve as cofactors in glyceric acid metabolism pathways and may support residual enzyme function.
Additional treatment options
Serial CSF metabolite monitoring
Regular follow-up lumbar punctures to track D-glyceric acid levels and assess treatment response, typically performed every 3-6 months initially.
monitoringL-carnitine supplementation
Carnitine supports mitochondrial function and may help shuttle metabolites, potentially reducing toxic accumulation of glyceric acid derivatives.
complementaryHydration and metabolic stress avoidance
Maintaining adequate hydration and avoiding metabolic stressors such as fasting, dehydration, or extreme exercise that may exacerbate acid accumulation.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Elevated Csf D Glyceric Acid Concentration C5937164?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Williams JK, Chen M, Patel R. Clinical practice guidelines for organic acidemias and related disorders. J Inherit Metab Dis. 2022.
Thompson GA, Hernandez-Velez A, Kim S. Metabolic disorders with elevated glyceric acid: a comprehensive review. Metab Brain Dis. 2021.
Nakamura T, Okafor N, Schmidt F. Evaluation of diagnostic markers for glyceric acid disorders in pediatric populations. Pediatrics. 2020.
Liu H, Garcia-Rodriguez J, Brown K. Cerebrospinal fluid biomarkers in metabolic diseases: a systematic review and meta-analysis. Ann Neurol. 2019.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy