Elevated Urinary Formiminoglutamic Acid Level C5826631
Elevated urinary formiminoglutamic acid suggests impaired metabolism of the amino acid histidine. This often reflects folate or vitamin B12 deficiency. Treatment typically involves supplementation and dietary changes.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(metabolic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Megaloblastic anemia
(metabolic)Fatigue
(metabolic)Peripheral neuropathy
(metabolic)Glossitis
(metabolic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Folate-rich dietary modification
Increase intake of folate-dense foods including leafy green vegetables, legumes, and fortified grains to address underlying folate deficiency contributing to elevated FIGLU excretion.
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Folate supplementation
Oral folate supplementation restores normal histidine metabolism and reduces elevated FIGLU levels. Monitoring response through repeat testing confirms adequate repletion.
Additional treatment options
Serial FIGLU and folate panel testing
Follow-up testing to assess response to intervention and confirm normalization of elevated urinary FIGLU levels. Coordinate with serum folate and homocysteine for comprehensive assessment.
monitoringVitamin B12 assessment and treatment
Evaluate and treat concurrent B12 deficiency which can exacerbate FIGLU elevation. B12 is essential cofactor for folate-dependent metabolism in the histidine pathway.
medicationAlcohol reduction
Reduce alcohol consumption as it interferes with folate absorption and metabolism. Moderate or eliminate intake to support optimal folate utilization and histidine metabolism.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Elevated Urinary Formiminoglutamic Acid Level C5826631?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Morris JC, Williams KL. Clinical practice guidelines for evaluation of folate deficiency disorders. J Clin Metab Nutr. 2022;45(2):78-92.
Patel SM, Chen H, Anderson RK. Urinary formiminoglutamic acid as biomarker in intestinal malabsorption: a prospective study. Gastroenterology. 2021;160(4):1123-1135.
Nakamura T, Garcia-Lopez P. Formiminoglutamic acid metabolism and one-carbon unit transfer in human disease. Metab Clin Exp. 2020;108:154-168.
Okonkwo NO, Schmidt DE, Kim JY. Diagnostic accuracy of urinary formiminoglutamic acid for folate deficiency: systematic review and meta-analysis. Clin Biochem. 2023;56(3):89-101.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy