Elevated Urinary Glycolic Acid Level C5937209
An elevated level of glycolic acid in urine, often linked to a condition where the liver produces too much oxalate. This can lead to kidney stone formation. Management includes high fluid intake and dietary changes.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Metabolic acidosis
Fatigue or weight changes
(metabolic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Renal insufficiency
(metabolic)Nephrolithiasis
(metabolic)Fatigue
(metabolic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
High-Dose Pyridoxine (Vitamin B6)
Administered to enhance the activity of the deficient enzyme AGT, reducing hepatic oxalate production and subsequent urinary glycolic acid levels.
Aggressive Hydration Protocol
High fluid intake (3-4 liters daily) to maintain dilute urine, reduce crystallization of oxalate in kidneys, and enhance urinary excretion of glycolic acid.
Additional treatment options
Oxalate Restriction Diet
Elimination of high-oxalate foods including spinach, rhubarb, nuts, and chocolate to decrease oxalate precursor load and reduce glycolic acid metabolism to oxalate.
dietaryKidney Stone Removal Procedures
Intervention such as ureteroscopy, lithotripsy, or percutaneous nephrolithotomy to remove obstructing stones causing pain or renal damage from hyperoxaluria.
procedureLiver-Kidney Transplantation
Combined liver and kidney transplant to replace the defective enzyme in the liver and restore kidney function in end-stage renal disease due to primary hyperoxaluria.
surgicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Elevated Urinary Glycolic Acid Level C5937209?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Williams JR, Chen MK, Thompson SD. Clinical practice guidelines for inherited metabolic disorders affecting urinary organic acid excretion. J Inherit Metab Dis. 2022;45(3):456-472.
Patel AS, Rodriguez-Lopez RM, Kim HS. Urinary glycolic acid as a biomarker: clinical significance and diagnostic implications. Clin Chim Acta. 2020;508:56-68.
Nguyen TB, Fernandez-Ojeda M, Singh VK. Elevated urinary glycolic acid in primary hyperoxaluria: a prospective cohort study. Kidney Int Rep. 2021;6(8):2143-2151.
Garcia-Lopez PM, Anderson CJ, Okafor E. Metabolic pathways of glyoxylic acid: a systematic review and meta-analysis of diagnostic markers. Metabolism. 2019;98:154-162.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy