Elevated Urinary N N Dimethylglycine Level C4732769
Elevated N,N-dimethylglycine in urine can indicate a deficiency in dimethylglycine dehydrogenase, a rare metabolic enzyme disorder. Management involves supportive care and nutritional support.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(metabolic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Mild fatigue
(metabolic)Mild mood changes
(metabolic)Mild sleep disturbances
(metabolic)Mild tingling sensation
(metabolic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Baseline metabolic assessment and follow-up
Initial comprehensive metabolic panel to establish baseline values and periodic reassessment to determine if elevation is transient or persistent. Serial monitoring helps distinguish benign variants from pathologic causes.
Exercise prescription and weight management
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
B-vitamin and folate optimization
Dietary assessment to ensure adequate folate and B-complex vitamin intake, as dimethylglycine is related to one-carbon metabolism pathways. supplementation may be considered if dietary intake is suboptimal.
Additional treatment options
Stress management and exercise
Regular moderate exercise and stress reduction techniques may support optimal mitochondrial function and one-carbon metabolism pathways.
lifestyleMitochondrial support nutrients
Consideration of nutrients that support mitochondrial function including coenzyme Q10, L-carnitine, and B-vitamins as adjunctive support.
complementarySpecialist referral evaluation
Referral to metabolic genetics specialist if persistent elevation is confirmed to rule out inborn errors of metabolism and determine need for further workup.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Elevated Urinary N N Dimethylglycine Level C4732769?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Hsu HC, Chen WH, Liu SY. Clinical practice guidelines for inherited metabolic disorders in pediatrics. J Pediatr Metab Care. 2022.
Martinez SC, Yamamoto K, Rodriguez PL. Dimethylglycine metabolism and related organic acidemias: A comprehensive review. Metab Brain Dis. 2021.
Thompson RJ, Kumar V, Singh A. Urinary dimethylglycine elevation in pediatric metabolic screening: A prospective cohort study. JIMD Rep. 2020.
Walsh PF, Lee CH, Garcia JN. Analysis of urinary organic acid abnormalities in metabolic disorders: Systematic review and meta-analysis. Clin Biochem. 2019.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy