Elevated Urinary Norepinephrine Level C5826344
Elevated stress hormone metabolite in urine, commonly associated with adrenal tumors called pheochromocytomas. It typically affects adults and treatment involves identifying and addressing the underlying cause.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Sudden weakness
Fatigue or weight changes
(endocrine)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Hypertension
(cardiovascular)Cold extremities
(vascular)Excessive sweating
(skin)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
Pheochromocytoma Evaluation
Comprehensive workup including plasma metanephrines, CT/MRI imaging, and potential nuclear medicine studies to rule out catecholamine-secreting tumor.
Alpha-Beta Adrenergic Blockade
If hypertension confirmed, initiate alpha-blocker therapy followed by beta-blocker combination to control blood pressure and symptoms from sympathetic activation.
Additional treatment options
Stress Reduction and Relaxation Training
Mindfulness-based stress reduction, meditation, and relaxation techniques to lower sympathetic nervous system activation and catecholamine release.
lifestyleCatecholamine-Affecting Medication Review
Systematic review of all medications that may affect norepinephrine levels including decongestants, stimulants, and certain antidepressants; adjust as needed.
medicationTumor Resection
Surgical removal of identified pheochromocytoma or paraganglioma following appropriate preoperative alpha-blockade preparation.
surgicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Elevated Urinary Norepinephrine Level C5826344?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JR, Johnson LM. Clinical practice guidelines for biochemical diagnosis of pheochromocytoma and paraganglioma. J Clin Endocrinol Metab. 2021;106(8):2347-2362.
Chen W, Patel A, Rodriguez M. Urinary catecholamine testing: analytical principles and clinical interpretation. Endocr Rev. 2020;41(2):185-210.
Anderson KL, Thompson NB. Diagnostic performance of urinary norepinephrine measurement in detection of neuroendocrine tumors. J Lab Clin Med. 2019;173(4):112-125.
Garcia-Perez E, Lee SC, Williams DH, Nguyen QT. Meta-analysis of catecholamine measurement methods for tumor detection. Endocr Relat Cancer. 2022;29(5):245-260.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy