Epidermolytic Hyperkeratosis 1 C5781874
A genetic skin condition causing thickened, scaly skin and blistering, typically present from birth or early infancy. It can affect any area of the body. Management includes moisturizers, keratolytic agents, and careful skin protection.
Key facts at a glance
- ICD-10
- Q84.9
- ICD-11
- LA00.0
- Body system
- dermatologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(dermatologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Topical Retinoid Therapy
Application of tretinoin or tazarotene creams to reduce hyperkeratosis and normalize skin cell turnover in epidermolytic ichthyosis.
Keratolytic Agent Treatment
Topical salicylic acid or urea-based preparations applied to thick hyperkeratotic areas to soften and remove excess scale buildup.
Additional treatment options
Intensive Hydration Protocol
Multiple daily applications of thick emollients and ointments immediately after bathing to trap moisture and reduce scale formation.
lifestyleMedicated Bath Therapy
Bathing with colloidal oatmeal, dead sea salts, or dilute potassium permanganate to soften scales and reduce bacterial overgrowth.
complementaryPhysical Therapy for Contracture Management
Stretching and mobilization exercises to prevent joint contractures from hyperkeratosis affecting skin flexibility.
physical_therapyWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Epidermolytic Hyperkeratosis 1 C5781874?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy