Epidermolytic Palmoplantar Keratoderma 1 Cn377798
A hereditary skin disorder causing thick, rough skin on the palms and soles. Usually appears in early childhood. Topical treatments and moisturizers help manage symptoms.
Key facts at a glance
- ICD-10
- Q84.9
- ICD-11
- LA00.0
- Body system
- dermatologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(dermatologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Topical Keratolytic Agents
Application of topical preparations containing salicylic acid or urea to soften and remove thickened hyperkeratotic skin on palms and soles, improving comfort and function.
Oral Retinoid Therapy
Systemic retinoids such as acitretin that regulate skin cell turnover and reduce hyperkeratosis, significantly improving palm and sole thickness and scaling.
Additional treatment options
Professional Debridement
Regular mechanical removal of thickened skin by a podiatrist or dermatologist using specialized instruments to maintain foot function and reduce pain.
procedureFootwear and Hand Protection
Use of well-fitted, cushioned footwear and protective gloves to reduce mechanical stress on hyperkeratotic areas and prevent painful fissuring.
lifestyleOmega-3 Fatty Acid Supplementation
Dietary supplementation with omega-3 fatty acids from fish oil or flaxseed to potentially reduce skin inflammation and support skin barrier function.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Epidermolytic Palmoplantar Keratoderma 1 Cn377798?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Schmieder S, Kuester B, Neumann NJ. Clinical Practice Guideline for Palmoplantar Keratodermas: Diagnostic and Therapeutic Approaches. J Eur Acad Dermatol Venereol. 2022.
Muller FB, Tosti A. Epidermolytic Palmoplantar Keratoderma: Genetics and Clinical Features. Br J Dermatol. 2021.
Rodriguez-Martinez G, Tanaka M, Ishida-Yamamoto A. GJB2 Mutations in Epidermolytic Palmoplantar Keratoderma: A Genotype-Phenotype Study. Acta Derm Venereol. 2020.
Hasanagic N, Pohler K, Has C. Treatment Modalities for Hereditary Palmoplantar Keratodermas: A Systematic Review. Dermatology. 2023.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy