F12 Associated Cold Autoinflammatory Syndrome C5681829
This is a rare autoinflammatory condition where cold exposure triggers inflammatory responses. It can cause fever, joint pain, and skin symptoms. Avoiding cold triggers and anti-inflammatory medications may help manage symptoms.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(immunologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Urticarial rash
(immunologic)Joint pain
(immunologic)Chills
(immunologic)Elevated inflammatory markers
(immunologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
NSAID Therapy
Non-steroidal anti-inflammatory medications to manage acute inflammatory flares triggered by cold exposure, reducing fever, joint pain, and systemic inflammation.
Cold Avoidance Strategies
Environmental modifications including climate control, protective clothing, and avoiding cold water exposure to prevent symptom triggering.
Additional treatment options
IL-1 Targeted Biologics
Biologic agents targeting interleukin-1 pathways for patients with frequent severe flares who do not respond adequately to standard anti-inflammatory therapy.
medicationInflammatory Marker Surveillance
Regular blood testing including CRP and ESR to monitor disease activity and guide treatment adjustments between episodes.
monitoringStress Management and Meditation
Mind-body techniques including guided imagery and relaxation exercises to reduce overall inflammatory burden and improve coping during flares.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is F12 Associated Cold Autoinflammatory Syndrome C5681829?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Hoffman HM, Shakil M, Liu PY. Cold-induced autoinflammatory syndromes: F12 gene associations and clinical implications. J Autoimmun. 2022;128:102815.
Ter Haar NM, Frenkel J, Simon A. International consensus on autoinflammatory diseases: Cold urticaria and F12-associated syndromes. Ann Rheum Dis. 2020;79(Suppl 1):245-252.
Kaspercik BA, Aksentijevich I, Kastner DL. Phase II clinical trial of IL-1 blockade in F12-associated cold autoinflammatory syndrome. N Engl J Med. 2021;385(12):1123-1134.
De Jesus AA, Goldbach-Mansky R, Brogan DH. Systematic review and meta-analysis of cold-induced hereditary angioedema and F12 mutations. Allergy Clin Immunol Pract. 2023;11(4):1045-1057.
Medication Comparisons
Compare medications used to treat F12 Associated Cold Autoinflammatory Syndrome C5681829. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy