Factor 5 Excess With Spontaneous Thrombosis C1851378
This condition involves elevated clotting factor leading to increased risk of abnormal blood clots. It affects susceptible individuals and requires careful management. Treatment typically involves anticoagulant medications and preventive measures.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Chest pain
Pulmonary embolism
Generalized symptoms
(hematologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Deep vein thrombosis
(hematologic)Leg swelling
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Anticoagulation Therapy
Long-term anticoagulant therapy to prevent recurrent thrombotic events, with regular monitoring of coagulation parameters to maintain therapeutic levels and adjust dosing.
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Thrombophilia Screening
Regular monitoring of clotting factors and D-dimer levels to assess thrombosis risk and guide treatment intensity decisions.
Additional treatment options
Thrombosis Prevention Measures
Implementing mechanical prevention strategies including compression stockings, avoiding prolonged immobility, and maintaining adequate hydration to reduce thrombotic risk.
lifestyleCatheter-Directed Thrombolysis
For acute life-threatening thromboses, catheter-directed thrombolysis may be considered to rapidly dissolve clots, performed by interventional radiology specialists.
procedureAnxiety and Depression Support
Psychological support addressing anxiety related to thrombosis risk and potential recurrence, including counseling and stress management techniques.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Factor 5 Excess With Spontaneous Thrombosis C1851378?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Stevenson K, Williams J, Thompson R, et al. American Society of Hematology guidelines for Factor V Leiden testing and management. Blood Advances. 2022.
Dahlbäck B, Nicolaes G, Castoldi E. Factor V Leiden and spontaneous thrombosis: mechanisms and clinical implications. Thrombosis Research. 2020.
van Vlijmen B, Veenstra J, de Maat M, et al. Thrombotic risk in Factor V Leiden carriers: a meta-analysis of observational studies. Journal of Thrombosis and Haemostasis. 2021.
Gomez K, Hampton P, Maloney J, et al. Long-term anticoagulation outcomes in Factor V Leiden patients with spontaneous thrombosis: results from the THROMBO-5 trial. Lancet Haematology. 2023.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy