Factor 9 And Factor Xi Combined Deficiency Of C1851374
A rare bleeding disorder caused by deficiency of two clotting factors. Patients may experience prolonged bleeding after injury or surgery.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
CNS hemorrhage
Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Hemarthrosis (joint bleeding)
(hematologic)Epistaxis (nosebleeds)
(hematologic)Intramuscular hematoma
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Factor replacement therapy
Replacement of deficient clotting factors using plasma-derived or recombinant factor IX and/or factor XI concentrates to prevent or treat bleeding episodes.
Targeted drug therapy with dose adjustment
Active treatment with regular monitoring by a healthcare provider is recommended.
Antifibrinolytic agents
Use of tranexamic acid or aminocaproic acid to stabilize clots and prevent fibrinolysis, particularly useful for mucosal bleeding and surgical prophylaxis.
Additional treatment options
Bleeding episode management
Acute management protocols for bleeding events including factor replacement, supportive care, and when indicated, advanced interventions such as embolization.
procedureBleeding prevention strategies
Implementation of injury prevention measures, avoidance of NSAIDs and anticoagulants, and use of medical alert identification to prevent and prepare for bleeding events.
lifestyleRegular hematology follow-up
Ongoing monitoring of factor levels, inhibitor screening, and comprehensive care coordination with hematology specialists for optimal disease management.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Factor 9 And Factor Xi Combined Deficiency Of C1851374?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy