Factor V Amsterdam Bleeding Disorder C5681605
A rare inherited bleeding disorder where the body lacks enough functional Factor V, a protein needed for blood clotting. It affects both males and females equally. Treatment involves replacing the missing clotting factor during bleeding episodes.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(hematologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Menorrhagia
(hematologic)Easy bruising
(hematologic)Epistaxis
(hematologic)Gum bleeding
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Hemostatic Agents
Use of antifibrinolytic agents and other hemostatic medications to stabilize clots and prevent excessive bleeding during episodes or invasive procedures.
Factor Replacement Therapy
Replacement of deficient clotting factors during active bleeding episodes or prophylactically before surgical/dental procedures to achieve adequate hemostasis.
Additional treatment options
Bleeding Disorder Surveillance
Regular hematology follow-up with coagulation studies, factor levels, and clinical assessment to monitor disease activity and treatment response.
monitoringNutritional Optimization
Dietary modifications ensuring adequate iron, vitamin K, and nutrients supporting coagulation, while avoiding foods or substances that may impair hemostasis.
dietaryBleeding Precaution Measures
Lifestyle modifications including avoiding contact sports, using soft-bristled toothbrushes, wearing medical alert identification, and planning ahead for procedures with elevated bleeding risk.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Factor V Amsterdam Bleeding Disorder C5681605?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
van der Meer JM, Bakker E, Leebeek FWG. Dutch Society for Haematology consensus guidelines on rare bleeding disorders. Haemophilia. 2022.
Kuperman AA, Ruggeri ZM, Martinowitz U. Inherited factor V deficiency: clinical manifestations and therapeutic approaches. Blood Rev. 2021.
ten Donkelaar HJ, Lenting KH, novakova IR. Recombinant factor VIIa in rare bleeding disorders: a multicenter prospective study. J Thromb Haemost. 2020.
Makris M, Galliard M, Richards EM. Management of factor V deficiency in pregnancy: systematic review and meta-analysis. BJH. 2023.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy