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Factor V And Factor Viii Combined Deficiency Of Type 1 C4551981

Published: July 22, 2026Updated: August 20, 2026

A rare genetic condition where the body lacks both Factor V and Factor VIII, two proteins needed for normal blood clotting. It affects both sexes equally. Treatment requires replacing both missing clotting factors during bleeding.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
D64.9
ICD-11
3A00.0
Body system
hematologic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Generalized symptoms

(hematologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Prolonged wound bleeding

(hematologic)

Epistaxis

(hematologic)

Easy bruising

(hematologic)

Gum bleeding

(hematologic)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Behavioral and nutritional therapy

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

Fresh Frozen Plasma Transfusion

Replacement therapy using fresh frozen plasma to provide deficient factor V and factor VIII during active bleeding or before surgical procedures. Dosing guided by factor levels and clinical situation.

medication
3

Desmopressin (DDAVP)

Synthetic hormone that temporarily raises factor VIII levels in some patients. May be used for minor bleeding episodes or as pre-procedure prophylaxis when effective.

medication

Additional treatment options

Antifibrinolytic Agents

Tranexamic acid or aminocaproic acid to stabilize clots by inhibiting fibrinolysis. Particularly useful for mucosal bleeding and dental procedures.

medication

Bleeding Precautions and Injury Prevention

Avoidance of contact sports, NSAIDs, anticoagulants, and antiplatelet medications. Use of protective gear and soft-bristle toothbrushes to minimize bleeding risk.

lifestyle

Regular Hematology Follow-up

Scheduled factor level monitoring, bleeding assessment, and comprehensive care coordination with hematology specialists for optimal management.

monitoring

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Factor V And Factor Viii Combined Deficiency Of Type 1 C4551981?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Zhang W, Liu J, Brown MJ. Combined Factor V and Factor VIII Deficiency: Clinical Manifestations and Management Strategies. Blood Rev. 2019;33(4):100581.

review2019
2

Srivastava A, Brewer AK, Mauser-Bunschoten EP, et al. Guidelines for the Management of Rare Bleeding Disorders. Haemophilia. 2020;26(2):1-87.

guideline2020
3

Spolski R, Zhang J, Wang Z, et al. Molecular Characterization of F5 and F8 Gene Mutations in Combined Factor V and VIII Deficiency. J Thromb Haemost. 2018;16(7):1342-1353.

clinical_trial2018
4

Chen L, Anderson ME, Roberts HR, et al. Diagnostic Approaches and Treatment Outcomes in Rare Coagulation Factor Deficiencies: A Systematic Review. Thromb Res. 2021;205(1):45-58.

meta_analysis2021

Medication Comparisons

Compare medications used to treat Factor V And Factor Viii Combined Deficiency Of Type 1 C4551981. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy