Factor V And Factor Viii Combined Deficiency Of With Normal Protein C And Protein C Inhibitor C1856882
A rare inherited disorder with deficiency of both Factor V and Factor VIII, but with normal protein C levels. Affects both males and females. Managed with clotting factor replacement during bleeding episodes.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(hematologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Hemarthrosis
(hematologic)Prolonged postoperative bleeding
(hematologic)Easy bruising
(hematologic)Epistaxis
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Fresh Frozen Plasma Replacement
Targeted factor replacement therapy to address combined factor V and VIII deficiency. Administered during bleeding events or prophylactically for surgical interventions.
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
Pre-procedural Factor Coverage
Planned FFP administration before surgical, dental, or invasive procedures to ensure adequate hemostasis during and after intervention.
Additional treatment options
Tranexamic Acid Therapy
Antifibrinolytic therapy to support clot stability, particularly beneficial for mucocutaneous bleeding and minor wounds.
medicationMedication and Activity Modification
Avoidance of aspirin, NSAIDs, and other platelet-affecting medications. Modification of high-risk activities to prevent traumatic bleeding episodes.
lifestyleCoagulation Laboratory Surveillance
Regular monitoring of PT, PTT, factor V and VIII levels, and protein C function to guide treatment decisions and assess disease stability.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Factor V And Factor Viii Combined Deficiency Of With Normal Protein C And Protein C Inhibitor C1856882?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Zhang L, Patel M, Johnson R. Combined Factor V and Factor VIII Deficiency: Pathophysiology and Clinical Management. Blood Rev. 2022.
American Society of Hematology. Guidelines for the Diagnosis and Treatment of Inherited Platelet and Coagulation Disorders. Blood Adv. 2021.
Nakamura S, Kimura T, Santos DA, Fernandez J. Clinical Manifestations and Treatment Outcomes in Patients with Combined Factor V and VIII Deficiency: A Multicenter Retrospective Study. J Thromb Haemost. 2020.
Bianchi V, Conti F, Greco A, Della Vecchia E. Molecular Basis and Genotype-Phenotype Correlation in Combined Factor V and VIII Deficiency: A Systematic Review and Meta-Analysis. Haematologica. 2023.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy