Familial Adenomatous Polyposis 2 C3272841
Familial adenomatous polyposis 2 is a hereditary disorder causing multiple colorectal polyps, similar to FAP1 but from different genetic causes. Without treatment, there is a very high lifetime risk of colon cancer. Regular screening and preventive interventions are essential.
Key facts at a glance
- ICD-10
- D13.91
- ICD-11
- 3A00.0
- Body system
- gastrointestinal
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Intestinal obstruction
Abdominal pain or nausea
(gastrointestinal)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Rectal bleeding
(gastrointestinal)Change in bowel habits
(gastrointestinal)Abdominal discomfort
(gastrointestinal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
GI disease management
Active treatment with regular monitoring by a healthcare provider is recommended.
Prophylactic colectomy with ileorectal anastomosis
Surgical removal of the colon while preserving the rectum, recommended when polyp burden becomes too numerous for endoscopic management. This is the definitive treatment to prevent colorectal cancer development.
NSAID therapy (sulindac or aspirin)
Non-steroidal anti-inflammatory medications have been shown to reduce the number and size of adenomatous polyps. These work by inhibiting cyclooxygenase enzymes and reducing prostaglandin synthesis.
Additional treatment options
Regular endoscopic surveillance program
Comprehensive monitoring including annual colonoscopy, upper endoscopy for duodenal polyps, and thyroid examination. Early detection of malignant transformation is critical.
monitoringEndoscopic polypectomy
Removal of polyps during colonoscopy or upper endoscopy to reduce cancer risk and manage symptoms when polyp burden is manageable. May require multiple sessions.
procedureLow-fat, high-fiber dietary modification
Dietary changes supporting colon health including increased fiber intake, reduced red meat consumption, and adequate hydration. May help reduce intestinal inflammation and slow polyp progression.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Familial Adenomatous Polyposis 2 C3272841?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy