Familial Adenomatous Polyposis 4 C4310719
A hereditary disorder causing numerous polyps in the colon due to APC gene changes. It affects families with this genetic mutation and requires lifelong monitoring with surgery often needed to prevent cancer.
Key facts at a glance
- ICD-10
- D13.91
- ICD-11
- 3A00.0
- Body system
- gastrointestinal
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Abdominal pain or nausea
(gastrointestinal)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Change in bowel habits
(gastrointestinal)Rectal bleeding
(gastrointestinal)Unexplained weight loss
(gastrointestinal)Desmoid tumor
(gastrointestinal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
GI disease management
Active treatment with regular monitoring by a healthcare provider is recommended.
Stage-appropriate prophylactic colectomy
Surgical timing determined by polyp burden, dysplasia grade, and family history. Early colectomy before cancer development significantly improves survival outcomes in FAP type 4.
Combination NSAID and EGFR inhibitor therapy
Emerging chemoprevention combining traditional NSAIDs with epidermal growth factor receptor inhibitors shows promise in reducing polyp burden in refractory cases.
Additional treatment options
Intensive polyp burden assessment
Quantitative polyp counting and mapping through chromoendoscopy or narrow band imaging to guide surgical timing and assess treatment response. Essential for personalized management.
monitoringArgon plasma coagulation ablation
Thermal ablation technique used to destroy small polyps and reduce rectal polyp burden when surgical intervention is delayed or as adjunct to surgery.
procedureAnti-inflammatory Mediterranean diet protocol
Mediterranean-style eating pattern emphasizing omega-3 fatty acids, vegetables, and olive oil may provide modest anti-inflammatory benefits and support overall colon health.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Familial Adenomatous Polyposis 4 C4310719?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy