Familial Cerebral Cavernous Malformation 4 Cn381156
An inherited condition causing abnormal clusters of blood vessels in the brain that can leak or cause seizures. It can affect multiple family members. Management includes monitoring and treating complications like seizures or bleeding.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Intracranial hemorrhage
Focal neurological deficit
Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Seizures
(neurologic)Headache
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Surgical Resection
Neurosurgical removal of symptomatic cavernous malformations causing seizures, hemorrhage, or neurological deficits. Goal is complete excision while minimizing damage to surrounding brain tissue.
Anticonvulsant Medications
Seizure-prevention medications prescribed when cavernous malformations cause epileptic activity. Choice depends on seizure type, patient age, and potential drug interactions.
Additional treatment options
Serial MRI Surveillance
Periodic magnetic resonance imaging to monitor known cavernous malformations for changes in size, evidence of hemorrhage, or development of new lesions. Frequency based on lesion characteristics and family history.
monitoringHemorrhage Risk Avoidance
Avoidance of activities and medications that increase bleeding risk, including contact sports, anticoagulants, and antiplatelet agents unless absolutely necessary for other conditions.
lifestylePsychological Support and Counseling
Mental health support for patients and families dealing with the uncertainty of a genetic cerebrovascular condition. Addresses anxiety, depression, and adjustment to living with a potentially progressive neurological condition.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Familial Cerebral Cavernous Malformation 4 Cn381156?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Morrison L, Fischer H, Chen S. Familial cerebral cavernous malformation type 4: genetic mechanisms and clinical management. Neurology. 2022.
Patel R, Kim JJ, Williams M, et al. Surgical outcomes in familial CCM4-related cavernous malformations: a prospective cohort study. J Neurosurg. 2021.
International Cavernous Malformation Study Group. Guidelines for diagnosis and management of familial cerebral cavernous malformations. Stroke. 2020.
Liu Y, Santos-Nunez J, Vega A, Thompson D. Molecular pathogenesis of CCM4 mutations in familial cerebral cavernous malformation type 4: a systematic review. Brain. 2023.
Medication Comparisons
Compare medications used to treat Familial Cerebral Cavernous Malformation 4 Cn381156. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy