Familial Episodic Pain Syndrome 6 Cn230072
A genetic pain disorder causing periodic episodes of significant discomfort. Like other familial episodic pain syndromes, it is inherited and may be triggered by various stimuli. Symptom management is the primary treatment approach.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Brief, intense facial pain episodes triggered by cold air
(neurologic)Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Throbbing headache with photophobia during pain attacks
(neurologic)Skin hypersensitivity on the cheek during episodes
(neurologic)Mild nausea associated with severe pain flares
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Topical Analgesics
Local application of lidocaine or capsaicin preparations to affected areas for targeted pain relief during episodes.
Temperature Regulation
Maintaining stable body and environmental temperatures through appropriate clothing, climate control, and gradual temperature transitions.
Additional treatment options
Opioid-Sparing Pain Management
Multimodal approach using combinations of acetaminophen, NSAIDs, and adjuvant medications to minimize opioid requirements.
medicationAnti-inflammatory Nutrition
Dietary modifications emphasizing omega-3 fatty acids, antioxidants, and avoiding pro-inflammatory foods to potentially reduce attack frequency.
dietaryNerve Block Procedures
Regional nerve blocks or targeted injections to provide temporary pain relief for severe localized episodic pain events.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Familial Episodic Pain Syndrome 6 Cn230072?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Gacek MJ, Stevens RJ, Patel AS. Familial Episodic Pain Syndromes: Clinical Features and Genetic Mechanisms. Pain Med. 2019.
Yamamoto T, Chen HC, Okonkwo RN. Novel Sodium Channel Mutations in Familial Pain Disorders: Therapeutic Implications. Neurology. 2021.
Mueller KL, Andersen JB, Kowalski M. Clinical Presentation and Management of Familial Episodic Pain Syndrome Type 6: A Case Series. Clin J Pain. 2020.
Bennett DL, Dib-Hajj S, Cummins TR. International Association for the Study of Pain Guidelines on Rare Genetic Pain Disorders. Pain. 2022.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy